Lack of association between TaqIA RFLP of the dopamine D2 receptor gene and alcoholism in type II Turkish alcoholics


Karaoguz M., Onen I. , Cosar B. , Arikan Z., Sahin F., Menevse A.

KOREAN JOURNAL OF GENETICS, vol.26, no.2, pp.149-154, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2004
  • Title of Journal : KOREAN JOURNAL OF GENETICS
  • Page Numbers: pp.149-154

Abstract

The D2 dopamine receptor (DRD2) gene is the first candidate gene that has shown promise of an association with alcoholism. A correlation between alcoholism and A1 and A2 alleles of this gene has been under research. In this study, in order to determine the frequencies of allele polymorphisms in 52 unrelated type H alcoholics and in 93 unrelated controls, extraction of DNA was performed and appropriate condition of polymerase chain reaction (PCR) was established before TaqI enzyme digestion. To determine the significant difference in genotypes and allelic frequencies between the two groups, Fisher's exact test and Yates' corrected chi-square test were performed, respectively. No significant differences were found between the alcoholics and the controls in the current study in genotypes (p = 0.1600) and in the frequency of the A1 allele (p = 0.7513). As a result, the data from the study do not support the hypothesis that the A1 allele of the DRD2 gene has an association with alcoholism but it could have put additive effect on the determination of the racial differences in the allele frequencies of the TaqIA polymorphism.