INVESTIGATION OF NEUROTROPHIN LEVELS IN MULTIPAROUS WOMEN WITH STRESS URINARY INCONTINENCE

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Ünal K.

International Biochemistry Congreess 2023 // 34th National Biochemistry Congress , Muğla, Türkiye, 29 Ekim - 01 Kasım 2023

  • Yayın Türü: Bildiri / Yayınlanmadı
  • Basıldığı Şehir: Muğla
  • Basıldığı Ülke: Türkiye
  • Gazi Üniversitesi Adresli: Evet

Özet

NVESTIGATION OF NEUROTROPHIN LEVELS IN MULTIPAROUS WOMEN WITH STRESS URINARY INCONTINENCE
Kübranur Ünal1, Musa Latif Çöllüoğlu2, Elif Erdem3, Cansu Özbaş4, Leyla İbrahimkhanlı1, Özhan Özdemir3
1 Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye
2 Gazi University, Faculty of Medicine, Institute of Health Sciences, Ankara, Türkiye
3 University of Health Sciences, Faculty of Medicine, Department of Obstetrics and Gynaecology, Ankara, Türkiye
4 Gazi University, Faculty of Medicine, Department of Public Health, Ankara, Türkiye
Objectives: The aim of the study is to investigate serum neurotrophin (NT) levels to understand how those molecules were changed in premenopausal multiparous women who suffer from stress-related urinary incontinence namely stress urinary incontinence (SUI) and mixed urinary incontinence (MUI). Diagnostic and distinguishing capabilities of the NTs for those disorders is also evaluated in the study.
Materials and methods: Pre-menopausal multiparous women underwent a urodynamic examination, stress cough test and ICIQ-SF questionnaire.  Participants have divided into three groups: a control group of healthy women and two patient groups of women diagnosed with SUI and MUI. Their venous blood was taken, and serum NTs were measured by ELISA. The data obtained from patients were compared between groups. ROC analysis was performed to determine the role of NTs in diagnosing urinary incontinence.
Results: The result showed that the serum NGF and NT-3 levels in both incontinence subtypes are significantly low compared to the control. BMI score and number of VD are higher in incontinence subtypes compared to control, and ICIQ-SF score is more elevated in MUI compared to SUI.
Conclusions: The differences in serum NT levels were observed in pre-menopausal multiparous patients with urinary incontinence. Serum NGF levels in MUI patients and serum NT-3 levels in SUI patients tend to be decreased. Although the significance in serum levels change of NGF and NT-3, their discriminatory potential was weak or moderate.
 
Keywords:Mixed urinary incontinence, multiparous, neurotrophin, pre-menopause, stress urinary incontinence