Effects of epidermal growth factor on lipid peroxidation and nitric oxide levels in oral mucosal ulcer healing: A time-course study

Coskun Ş., Guelec E. G., Balabanli B., Acartuerk F.

SURGERY TODAY, vol.37, no.7, pp.570-574, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 7
  • Publication Date: 2007
  • Doi Number: 10.1007/s00595-006-3455-7
  • Journal Name: SURGERY TODAY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.570-574
  • Keywords: epidermal growth factor implantation, lipid peroxidation, mucosal healing, nitric oxide, antioxidant, FORMULATION, SYNTHASE, STRESS, RATS, DAMAGE, ALPHA, EGF
  • Gazi University Affiliated: Yes


Purpose. Epidermal growth factor (EGF) has been used as a vulnerary agent. Epidermal growth factor accelerates wound healing. Nitric oxide (NO) is considered to be an important factor which is involved in wound healing. The objective of this study was to examine the effects of interactions between exogenous EGF and NOx which may have either similar or quite opposed properties in the process of oral wound repair on different days. In addition, lipid peroxidation was found to be an indicator of free radical damage.