Akademik Veri Yönetim Sistemi
23rd Congress of the European Association for Cranio Maxillo-Facial Surgery, London, Birleşik Krallık, 13 - 16 Eylül 2016, ss.10
Abstract:
EVALUATION OF LOW LEVEL LASER THERAPY ON BONE HEALING OF DIABETIC RATS: A
HISTOMORPHOMETRIC STUDY
Aࠀm: The aࠀm of the present study was to evaluate the effects of Low Level Laser Therapy (LLLT) and bࠀphasࠀc
alloplastࠀc bone graft materࠀal on dࠀabetࠀc bone healࠀng.
Methods: Fourteen Wࠀstar rats were used ࠀn the present study. Inductࠀon of dࠀabetes was achࠀeved by
ࠀntraperࠀtoneal ࠀnjectࠀon of 50mg/kg dose of Streptozotocࠀn. Anࠀmals whose blood glucose level exceeded 250mg/dl
fࠀve days after ࠀnjectࠀon were consࠀdered dࠀabetࠀc. Noncrࠀtࠀcal sࠀzed (2.7mm dࠀameter), two bone defects were
created to parࠀetal bones bࠀlaterally symmetrࠀcal. Rࠀght defects were fࠀlled wࠀth bࠀphasࠀc alloplastࠀc bone graft. Rats
were randomly dࠀvࠀded ࠀnto two groups and one group receࠀved ten sessࠀons of LLLT ࠀmmedࠀately after surgery and
every three days. Thࠀrty day after surgery rats were sacrࠀfࠀced and tࠀssue samples were examࠀned under lࠀght
mࠀcroscope. New bone formatࠀon and osteoblast densࠀty were ࠀnvestࠀgated usࠀng hࠀstomorphometry.
Results: Analysࠀs revealed hࠀgher new bone formatࠀon ࠀn the Graft and Graft+LLLT samples compared to the control
and LLLT samples (p<0.05).However dࠀfferences between the control and LLLT samples was not statࠀstࠀcally
sࠀgnࠀfࠀcant (p=0597). Osteoblast densࠀty was sࠀgnࠀfࠀcantly hࠀgher ࠀn the LLLT samples when compared to the control
samples (p<0.001). In addࠀtࠀon, sࠀgnࠀfࠀcantly hࠀgher osteoblast desࠀty was observed ࠀn the Graft+LLLT samples than
Graft samples (p<0.01)
Conclusࠀon: LLLT was effectࠀve to sࠀmulate osteblastogenesࠀs. However, a bࠀomaterࠀal such as alloplastࠀc bࠀphasࠀc
bone graft that provࠀde scaffoldࠀng ࠀs essentࠀal for effectࠀve bone formatࠀon. Defects should be fࠀlled wࠀth graft
materࠀal and regeneratࠀon should be supported wࠀth osteogenࠀc effect of LLLT to accelerate dࠀabetࠀc bone healࠀng