Ultrastructure of rat pup's Purkinje neurons whose mothers were exposed to ethanol during pregnancy and lactation

Koksal M., Ilgaz C., Erdogan D., Ozogul C., Tong E., Kalender H.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.115, ss.1669-1686, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 115 Konu: 12
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/00207450590958510
  • Sayfa Sayıları: ss.1669-1686


This study was intended to investigate the effects of alcohol on the ultrastructure of fetal cerebellar Purkinje cells. Twelve adult female rats of Sprague-Dawney species were utilized. Control and experiment groups were formed. Rats were made pregnant. Rats in experiment group were administered liquid diet containing 6% alcohol. Cerebellums of infant rats were taken on 6th, 8th, and 10th days after birth. For electron microscopy, tissue sections were processed and stained with the usual methods. When control and experiment groups were compared for electron microscopic investigation, degeneration of mithocondria as cristolysis, dilatations of rough endoplasmic reticulum tubuli, and ring-shaped appearance of Golgi apparatus unit were determined. In some groups, nuclear membrane disintegrated. In cytoplasms of Purkinje cells, multivesicular bodies were distinguished. It was determined that liquid diet containing 6% alcohol had toxic effects on Purkinje cells and caused ultrastructural signs of degeneration in these cells.