Synthesis and analgesic and anti-inflammatory activity of methyl 6-substituted-3(2H)-pyridazinone-2-ylacetate derivatives


Sahin M., Badicoglu B., Gokce M., Kupeli E., Yesilada E.

ARCHIV DER PHARMAZIE, vol.337, no.8, pp.445-452, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337 Issue: 8
  • Publication Date: 2004
  • Doi Number: 10.1002/ardp.200400896
  • Title of Journal : ARCHIV DER PHARMAZIE
  • Page Numbers: pp.445-452

Abstract

A series of methyl 6-substituted-3(2H)-pyridazinone-2-ylacetates 9 were synthesized and their analgesic and anti-inflammatory effects were evaluated in the phenylbenzoquinone-induced writhing test (PBQ test) and carrageenan-induced paw edema method, respectively. Side effects of the compounds were examined on gastric mucosa. None of the compounds showed gastric ulcerogenic effect compared with reference nonsteroidal anti-inflammatory drugs. Methyl 6-(4-(4-fluorophenyl)piperazine)-3(2H)-pyridazinone-2-ylacetate 9e was found to be more active than acetylsalicylic acid (ASA). Methyl 6-(4-(2-ethoxyphenyl)piperazine)-3(2h)-pyridazinone-2-ylacetate 9c has shown an anti-inflammatory activity as compared to the standard compound indometacin at the carrageenan-induced paw edema method.