Synthesis and analgesic and anti-inflammatory activity of methyl 6-substituted-3(2H)-pyridazinone-2-ylacetate derivatives

Sahin M., Badicoglu B., Gokce M., Kupeli E., Yesilada E.

ARCHIV DER PHARMAZIE, cilt.337, sa.8, ss.445-452, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 337 Sayı: 8
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/ardp.200400896
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.445-452
  • Anahtar Kelimeler: 3(2H)-pyridazinones, arylpiperazinylpyridazinones, analgesic activity, anti-inflammatory activity, ANTINOCICEPTIVE ACTIVITY, 3(2H)-PYRIDAZINONE DERIVATIVES, PYRIDAZINONE DERIVATIVES, UNITED-STATES, AGENTS, PHENYLBUTAZONE, INHIBITORS, DRUGS, 4-ETHOXY-2-METHYL-5-MORPHOLINO-3(2H)-PYRIDAZINONE, CYCLOOXYGENASE
  • Gazi Üniversitesi Adresli: Hayır

Özet

A series of methyl 6-substituted-3(2H)-pyridazinone-2-ylacetates 9 were synthesized and their analgesic and anti-inflammatory effects were evaluated in the phenylbenzoquinone-induced writhing test (PBQ test) and carrageenan-induced paw edema method, respectively. Side effects of the compounds were examined on gastric mucosa. None of the compounds showed gastric ulcerogenic effect compared with reference nonsteroidal anti-inflammatory drugs. Methyl 6-(4-(4-fluorophenyl)piperazine)-3(2H)-pyridazinone-2-ylacetate 9e was found to be more active than acetylsalicylic acid (ASA). Methyl 6-(4-(2-ethoxyphenyl)piperazine)-3(2h)-pyridazinone-2-ylacetate 9c has shown an anti-inflammatory activity as compared to the standard compound indometacin at the carrageenan-induced paw edema method.