Autonomic nervous system dysfunction and serum levels of neurotoxic and neurotrophic cytokines in patients with cobalamin deficiency

Ceneli O., Aki S. Z., Kucuk B. C., Tokcaer A. B., Kuruoglu R., Yagci M.

TURKISH JOURNAL OF HEMATOLOGY, cilt.27, sa.4, ss.250-256, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.5152/tjh.2010.46
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.250-256
  • Anahtar Kelimeler: Cobalamin deficiency, autonomic dysfunction, dysautonomia, autonomic neuropathy, serum cytokine levels, EPIDERMAL-GROWTH-FACTOR, HEART-RATE-VARIABILITY, NECROSIS-FACTOR-ALPHA, VITAMIN-B-12 DEFICIENCY, CEREBROSPINAL-FLUID, SPINAL-CORD, ABNORMALITIES, RATS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: The imbalance between neurotoxic cytokine tumor necrosis factor-alpha (TNF-alpha) and neurotrophic cytokines epidermal growth factor (EGF) and interleukin-6 (IL-6) plays a role in the pathogenesis of cobalamin (Cbl) deficiency-induced neuropathy. The aim of this study was to evaluate autonomic nervous system dysfunction and to look for any relationship between autonomic nervous system disturbances and serum cytokine levels (TNF-alpha, EGF, IL-6) in patients with Cbl deficiency.