Autonomic nervous system dysfunction and serum levels of neurotoxic and neurotrophic cytokines in patients with cobalamin deficiency


Ceneli O., Aki S. Z. , Kucuk B. C. , Tokcaer A. B. , Kuruoglu R., Yagci M.

TURKISH JOURNAL OF HEMATOLOGY, vol.27, no.4, pp.250-256, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.5152/tjh.2010.46
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.250-256
  • Keywords: Cobalamin deficiency, autonomic dysfunction, dysautonomia, autonomic neuropathy, serum cytokine levels, EPIDERMAL-GROWTH-FACTOR, HEART-RATE-VARIABILITY, NECROSIS-FACTOR-ALPHA, VITAMIN-B-12 DEFICIENCY, CEREBROSPINAL-FLUID, SPINAL-CORD, ABNORMALITIES, RATS
  • Gazi University Affiliated: Yes

Abstract

Objective: The imbalance between neurotoxic cytokine tumor necrosis factor-alpha (TNF-alpha) and neurotrophic cytokines epidermal growth factor (EGF) and interleukin-6 (IL-6) plays a role in the pathogenesis of cobalamin (Cbl) deficiency-induced neuropathy. The aim of this study was to evaluate autonomic nervous system dysfunction and to look for any relationship between autonomic nervous system disturbances and serum cytokine levels (TNF-alpha, EGF, IL-6) in patients with Cbl deficiency.