Evaluation of Susceptibility Testing by Comparison of Broth Microdilution and Disk Agar Diffusion Tests

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Özçelik B., Kaynak F., Abbasoğlu U.

Turkish Journal Of Pharmaceutical Sciences, vol.1, no.2, pp.77-85, 2004 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 1 Issue: 2
  • Publication Date: 2004
  • Journal Name: Turkish Journal Of Pharmaceutical Sciences
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.77-85
  • Gazi University Affiliated: Yes


There are methods for susceptibility testing for microorganisms that are isolated from different clinical samples. In order to obtain reliable results, many researchers have been working on the sensitivity of susceptibility tests and comparing the different methods. Staphylococci are important bacteria that commonly come out as causative agents in many infections with both hospital and community origin. Accurate breakpoint of Staphylococcus aureus is crucial in the management and treatment of both colonized and infected patients. To determine the in-vitro activity of trimethoprim-sulphamethoxazole, penicillin, tetracycline, vancomycine and erythromycin agents against S.aureus, isolates were collected from Naflide Halil Gelendost Primary School students of ages 7-12 were studied with microdilution and disk diffusion method. After comparison of the two methods results according to NCCLS criteria, in the 65 strains 97.5% correlation was determined.

Key words: Susceptibility tests, Disk diffusion method,Microdilution methods