Association of Fat-free Mass Index and Body Mass Index on Pulmonary Function Tests in Children with Rheumatological Disease-associated Interstitial Lung Disease Zusammenhang zwischen Fettfreiemasseindex und Body-massindex und den Lungenfunktionstests bei Kindern mit rheumatologisch assoziierter interstitieller Lungenerkrankung
Klinische Padiatrie, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1055/a-2875-4698
- Dergi Adı: Klinische Padiatrie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: atmungsfunktionen, body-mass-index, kind, lunge
- Gazi Üniversitesi Adresli: Evet
Özet
Introduction Rheumatological diseases may cause interstitial lung damage. This study aimed to investigate the association between pediatric body composition parameters and interstitial lung disease in patients with rheumatological conditions. Methods In this cross-sectional study, all patients aged 8-18 years with rheumatological diseases and chronic respiratory symptoms were evaluated for interstitial lung disease using spirometry, thorax computed tomography, and carbon monoxide diffusion tests. Nutritional status and body composition were assessed using bioelectrical impedance analysis, body mass index, and fat-free mass index. Patients were categorized into three groups, group I (normal fat-free mass index and body mass index), group II (sarcopenia-low fat-free mass index but normal body mass index), and group III (malnutrition with both low fat-free mass index and body mass index). Results A total of 26 patients were included, and the median age was 169.03 (94-216) months. The median body mass index was 21.9 (14.4-33.8) kg/m2. Sixteen (62 %) patients had normal body mass index and normal fat-free mass index (group I), four (15 %) patients had normal body mass index and low fat-free mass index (group II), and six (23 %) patients had low body mass index and low fat-free mass index (group III). Among the pulmonary function tests, the median (interquartile range) carbon monoxide diffusion tests z-score was - 2.3 ( - 4.9 to 0.06). A positive correlation was found between carbon monoxide diffusion tests z-scores and fat-free mass index (r = 0.589, p = 0.002). Fat-free mass index was significantly lower in the group with carbon monoxide diffusion tests z-scores of < - 1.64. Conclusions Nutritional status may be associated with pulmonary function test results in children with interstitial lung disease- related rheumatological diseases.