The aim of the study was to investigate the effects of local application of aminoguanidine (AMG) to oral mucosal wound or systemic administration application of AMG on the protein oxidation and antioxidant parameters and changes of inflammatory cytokines plasma. New-Zealand rabbits (n = 18) were used in the study. A standart incision was applied to the oral mucosa rabbits. Rabbits were divided into three groups as: Untreated incisional group (group I), local polyethylene glycol (PEG) + AMG (12.7 mg) bead (group II), and subcutaneous (sc) AMG administrated group (100 mg/kg for 3 days) (group III). Plasma tumor necrosis factor-alpha (TNF-alpha), interferongamma (IFN-gamma), advanced oxidation protein products (AOPP) levels and superoxide dismutase (SOD), glutathione peroxidase (GPx) activities were measured.