EFFECTS OF AMINOGUANIDINE AND WOUND HEALING OF THE RABBIT ON PLASMA ANTIOXIDANT STATUS, PROTEIN OXIDATION, AND INFLAMMATION


Karatas F., Yildirim Z., Akbulut K. G. , Ozer Ç., Acarturk F., Erbas D.

OXIDATION COMMUNICATIONS, vol.39, no.4, pp.2938-2945, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 4
  • Publication Date: 2016
  • Journal Name: OXIDATION COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.2938-2945
  • Keywords: aminoguanidine, wound healing, protein oxidation, antioxidants, inflammation, NITRIC-OXIDE, STRESS, INJURY, THERAPY, NO
  • Gazi University Affiliated: Yes

Abstract

The aim of the study was to investigate the effects of local application of aminoguanidine (AMG) to oral mucosal wound or systemic administration application of AMG on the protein oxidation and antioxidant parameters and changes of inflammatory cytokines plasma. New-Zealand rabbits (n = 18) were used in the study. A standart incision was applied to the oral mucosa rabbits. Rabbits were divided into three groups as: Untreated incisional group (group I), local polyethylene glycol (PEG) + AMG (12.7 mg) bead (group II), and subcutaneous (sc) AMG administrated group (100 mg/kg for 3 days) (group III). Plasma tumor necrosis factor-alpha (TNF-alpha), interferongamma (IFN-gamma), advanced oxidation protein products (AOPP) levels and superoxide dismutase (SOD), glutathione peroxidase (GPx) activities were measured.