Impact of oxidative stress on early postoperative knee function and muscle injury biochemical markers: Is it possible to create an ischemic preconditioning effect in sequential ischemic surgical procedures?

Aktas E., Atay C., DEVECİ M. A., ARIKAN Ş. M., Togral G., Yildirim A.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.49, no.4, pp.387-393, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3944/aott.2015.14.0352
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.387-393
  • Keywords: Bilateral total knee arthroplasty, ischemia-reperfusion injury, ischemic precondition effect, tourniquet, REPERFUSION INJURY, INFLAMMATORY RESPONSE, ARTHROPLASTY PATIENTS, SKELETAL-MUSCLE, NITRIC-OXIDE, LUNG INJURY, TOURNIQUET, REPLACEMENT, ACTIVATION, RADICALS
  • Gazi University Affiliated: No


Objective: Simultaneous bilateral total knee arthroplasty (TKA) with prolonged tourniquet time has the potential to trigger ischemia-reperfusion injury, which can adversely affect knee function. Studies suggest that the magnitude of injury is less if it occurs following an ischemic event which takes place in another part of the body, known as ischemic preconditioning (IPC). The purpose of this study was to investigate the impact of oxidative stress on muscle injury and knee function and to elucidate if potential IPC effect can attenuate ischemia-reperfusion injury metabolites and prevent poor functional outcomes in single-stage bilateral TKA.