Akademik Veri Yönetim Sistemi
Gazi Medical Journal, cilt.8, sa.3, ss.110-113, 1997 (Scopus)
Purpose: The effect of Clostridium histolyticum collagenase on wound healing was investigated and compared to commonly used 0.9% sodium chloride, 10% povidon-iodine and chlorhexidine acetate gauze. Methods: Four 1cm2 full- thickness skin defects created surgically in guinea pigs were treated daily with topical 10% povidon-iodine, chlorhexidine acetate gauze, collagenase, or 0.9% sodium chloride as for the control. Follow-up was made with standard photo-documentation until complete would healing, and wound healing periods were figured out by computerized digital analysis. On the 9th postoperative day, wounds from 10 animals were scored histologically according to their epithelization, cell content, granulation tissue, collagen deposition, and vascularly. Results: The earliest wound healing was seen in the collagenase - applied wounds (16.2 ± 0.3 days) which was statistically significant (p<0.05). However, histological scores failed to show any considerable difference between the groups (p>0.05) for all comparisons. Conclusion: Daily topical collagenase application to full thickness skin defects in guinea pig accelerated wound healing, but the mechanism that underlies this enhanced wound healing process still needs further investigations.