Role of Tenoxicam in The Prevention of Postlaminectomy Peridural Fibrosis in Rats

Karatay M., Celik H., KÖKTEKİR E., Karatay E., Sertbas I., Yilmaz A., ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.30, no.3, pp.559-565, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.559-565
  • Gazi University Affiliated: Yes


Aim: The reason behind failed back syndrome in some cases may be peridural fibrosis following spinal surgery. Many attempts have been shown to stop formation of peridural fibrosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the inflammatory and fibroblastic response. One of the most effective nonsteroidal anti-inflammatory drugs is tenoxicam, an oxicam derivative. This study suggests that topical application of tenoxicam is an effective way of preventing spinal peridural fibrosis developing after laminectomy in rats.