Role of Tenoxicam in The Prevention of Postlaminectomy Peridural Fibrosis in Rats

Karatay M., Celik H., KÖKTEKİR E., Karatay E., Sertbas I., Yilmaz A., ...Daha Fazla

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.30, sa.3, ss.559-565, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2013
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.559-565
  • Gazi Üniversitesi Adresli: Evet

Özet

Aim: The reason behind failed back syndrome in some cases may be peridural fibrosis following spinal surgery. Many attempts have been shown to stop formation of peridural fibrosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the inflammatory and fibroblastic response. One of the most effective nonsteroidal anti-inflammatory drugs is tenoxicam, an oxicam derivative. This study suggests that topical application of tenoxicam is an effective way of preventing spinal peridural fibrosis developing after laminectomy in rats.