Even though globe luxation is a quite rare eye problem observed in the pediatric emergency department, it is quite vital since it causes loss of vision. An 8-month-old male patient presented with the complaint of spontaneous eye protrusion. Eye manipulations that would increase intraocular pressure were avoided and the eye was quickly covered with a dressing to keep the eye wet. The eyeball was placed back performing lateral canthotomy. Unlike the other cases in the literature, the present case is a case of spontaneous and recurrent globe luxation in an infant with a syndromic facial appearance. Early diagnosis and management of the cases will prevent the development of complications.