Adrenocorticotropic Hormon-Secreting Pheochromocytoma: A Rare Cause of Cushing's Syndrome
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.23, sa.2, ss.125-129, 2019 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.25179/tjem.2018-63374
- Dergi Adı: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.125-129
- Anahtar Kelimeler: Ectopic Cushing's syndrome, pheochromocytoma, ACTH staining
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Pheochromocytoma is a rare cause of ectopic Cushing's syndrome and presents a challenge to the clinician in the diagnosis and treatment. In this study, a rare case of adrenocorticotropic hormone-producing pheochromocytoma is presented. A 55-years-old man with the symptoms of hypercortisolism, multidrug-resistant hypertension, and an adrenal mass is presented. The laboratory results were consistent with hypercortisolism, high plasma adrenocorticotropic hormone, high 24-hour urine metanephrine and normetanephrine and severe hypokalemia. Abdominal computerized tomography showed a 3-cm non-adenoma left adrenal mass. After preoperative management, left adrenalectomy was performed. A histopathological examination revealed a 2.5 cm pheochromocytoma with focal positivity for adrenocorticotropic hormone. The patient was discharged with full recovery under hydrocortisone replacement therapy. Furthermore, six weeks after the operation, 24-hour urinary excretion of metanephrine and normetanephrine was within normal ranges. In conclusion, an adrenocorticotropic hormone-producing pheochromocytoma should be considered in patients with clinical manifestations of ectopic Cushing's syndrome and adrenal mass.