Prognosis of hospitalized patients with community-acquired pneumonia

Akyil F. T., Yalcinsoy M., Hazar A., Cilli A., Celenk B., Kilic O., ...Daha Fazla

Revista Portuguesa de Pneumologia (English Edition), cilt.24, sa.3, ss.164-169, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.rppnen.2017.07.010
  • Dergi Adı: Revista Portuguesa de Pneumologia (English Edition)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.164-169
  • Anahtar Kelimeler: Alanin aminotransferase, BUN/albumin, Charlson cornorbidity score, Pneumonia, PSI score, Survival, LONG-TERM MORTALITY, FOLLOW-UP, POPULATION, COHORT, RISK, VALIDATION, ADULTS, MANAGEMENT, MORBIDITY, SEVERITY
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2017 Sociedade Portuguesa de PneumologiaIntroduction: The long-term prognosis of patients with community-acquired pneumonia (CAP) has attracted increasing interest in recent years. The objective of the present study is to investigate the short and long-term outcomes in hospitalized patients with CAP and to identify the predictive factors associated with mortality. Patients and methods: The study was designed as a retrospective, multicenter, observational study. Hospitalized patients with CAP, as recorded in the pneumonia database of the Turkish Thoracic Society between 2011 and 2013, were included. Short-term mortality was defined as 30-day mortality and long-term mortality was assessed from those who survived 30 days. Predictive factors for short- and long-term mortality were analyzed. Results: The study included 785 patients, 68% of whom were male and the mean age was 67 ± 16 (18–92). The median duration of follow-up was 61.2 ± 11.8 (37–90) months. Thirty-day mortality was 9.2% and the median survival of patients surviving 30 days was 62.8 ± 4.4 months. Multivariate analysis revealed that advanced age, the absence of fever, a higher Charlson comorbidity score, higher blood urea nitrogen (BUN)/albumin ratios and lower alanine aminotransferase (ALT) levels were all predictors of long-term mortality. Conclusion: Long-term mortality following hospitalization for CAP is high. Charlson score and lack of fever are potential indicators for decreased long-term survival. As novel parameters, baseline BUN/albumin ratios and ALT levels are significantly associated with late mortality. Further interventions and closer monitoring are necessary for such subgroups of patients.