Synthesis, characterization and anti-inflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo[3,2-b]-1,2,4-triazol-5-ols


Tozkoparan B., Gokhan N., Kupeli E., Yesilada E., Ertan M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.54, no.1, pp.35-41, 2004 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2004
  • Title of Journal : ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Page Numbers: pp.35-41

Abstract

A series of 6-(alpha-amino-4-chlorobenzyl) thiazolo[3,2-b]-1,2,4-triazol-5-ols (2a-j) were synthesized from 6-(4-chlorobenzylidene)thiazolo[3,2-b]-1,2,4-triazolo-5(6H)-one (2) by applying Michael addition reaction. All the compounds were characterized by their melting points, elementary analysis, IR and H-1-NMR spectra and screened for their anti-inflammatory and analgesic activities. Among the derivatives compound 2i bearing 4-(4-acetylphenyl)piperazine showed the highest and dose-dependent analgesic and anti-inflammatory activity without inducing any gastric lesion.