SYNTHESIS, CHARACTERIZATION AND pBR322 PLASMID DNA INTERACTION OF PLATINUM(II) COMPLEXES WITH IMIDAZOLE AND 2-PHENYLIMIDAZOLE AS CARRIER LIGANDS

Bogatarkan C., UTKU S., AÇIK L.

REVUE ROUMAINE DE CHIMIE, cilt.60, sa.1, ss.59-64, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 1
  • Basım Tarihi: 2015
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.59-64
  • Gazi Üniversitesi Adresli: Evet

Özet

A series of platinum(H) complexes involving a physiologically active imidazole (Im) and 2-phenylimidazole (Pim) as carrier ligands of the types [Pt(Im)(2)X-2] and [Pt(Pim)(2)X-2] (X= -Cl or -I) were synthesized and characterized by their elemental analyses, IR. H-1 NMR and ESI-LC/MS. The plasmid DNA interactions of the platinum compounds were also investigated using Agarose Gel Electrophoresis method. According to plasmid DNA interaction studies, synthesized complexes modified the tertiary structure of pBR322 plasmid DNA.