SYNTHESIS, CHARACTERIZATION AND pBR322 PLASMID DNA INTERACTION OF PLATINUM(II) COMPLEXES WITH IMIDAZOLE AND 2-PHENYLIMIDAZOLE AS CARRIER LIGANDS


Bogatarkan C., UTKU S., AÇIK L.

REVUE ROUMAINE DE CHIMIE, vol.60, no.1, pp.59-64, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 1
  • Publication Date: 2015
  • Title of Journal : REVUE ROUMAINE DE CHIMIE
  • Page Numbers: pp.59-64

Abstract

A series of platinum(H) complexes involving a physiologically active imidazole (Im) and 2-phenylimidazole (Pim) as carrier ligands of the types [Pt(Im)(2)X-2] and [Pt(Pim)(2)X-2] (X= -Cl or -I) were synthesized and characterized by their elemental analyses, IR. H-1 NMR and ESI-LC/MS. The plasmid DNA interactions of the platinum compounds were also investigated using Agarose Gel Electrophoresis method. According to plasmid DNA interaction studies, synthesized complexes modified the tertiary structure of pBR322 plasmid DNA.