Serum interleukin 18 and tumour necrosis factor-alpha levels are increased in Behcet's disease

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Atıf İçin Kopyala

Oztas M. O., Onder M., Gurer M., Bukan N., Sancak B.

CLINICAL AND EXPERIMENTAL DERMATOLOGY, cilt.30, sa.1, ss.61-63, 2005 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 30 Sayı: 1
• Basım Tarihi: 2005
• Doi Numarası: 10.1111/j.1365-2230.2004.01684.x
• Dergi Adı: CLINICAL AND EXPERIMENTAL DERMATOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.61-63
• Gazi Üniversitesi Adresli: Evet

Özet

Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)-18 and tumour necrosis factor (TNF)-alpha levels of patients with Behcet's disease. Twenty-seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL-18 and TNF-alpha level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL-18 and TNF-alpha levels of Behcet patients (r(s) = 0.627, P < 0.0001). IL-18 and TNF-alpha levels may be related to disease pathogenesis. Increased levels of IL-18 also support Th1 predominance in Behcet's disease.