TCTP/HRF pathway and angiogenesis: A feasible intercourse in chronic lymphocytic leukemia

Yagci M., YEGİN Z. A., AKYÜREK N., KAYHAN H., ÖZKURT Z. N., Sucak G. T., ...More

LEUKEMIA RESEARCH, vol.37, no.6, pp.665-670, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1016/j.leukres.2013.01.005
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.665-670
  • Keywords: TCTP/HRF, Angiogenesis, Microvessel density, Mast cells, Histamine, Chronic lymphocytic leukemia, Prognosis, MARROW MICROVESSEL DENSITY, CONTROLLED TUMOR PROTEIN, MAST-CELLS, PROGNOSTIC VALUE, HISTAMINE, RANITIDINE, CANCER
  • Gazi University Affiliated: Yes


This prospective study was planned to determine the intercourse between translationally controlled tumor protein (TCTP)/histamine releasing factor (HRF)/histamine pathway and angiogenesis in chronic lymphocytic leukemia (CLL). A total of 153 CLL patients were included. Serum histamine levels were higher in CLL patients. A positive correlation was found between microvessel density (MVD)-mast cell (MC) count; MVD-TCTP/HRF and MC count-TCTP/HRF. Microvessel density, MC and ZAP 70 were significantly higher in TCTP/HRF-positive group. Time to first treatment was shorter in patients with increased MVD and TCTP/HRF. Further data is essential to ascertain the role of TCTP/HRF pathway in tumor angiogenesis and CLL prognosis. (C) 2013 Elsevier Ltd. All rights reserved.