TCTP/HRF pathway and angiogenesis: A feasible intercourse in chronic lymphocytic leukemia


Yagci M., YEGİN Z. A. , AKYÜREK N. , KAYHAN H. , ÖZKURT Z. N. , Sucak G. T. , ...Daha Fazla

LEUKEMIA RESEARCH, cilt.37, sa.6, ss.665-670, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 37 Konu: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.leukres.2013.01.005
  • Dergi Adı: LEUKEMIA RESEARCH
  • Sayfa Sayıları: ss.665-670

Özet

This prospective study was planned to determine the intercourse between translationally controlled tumor protein (TCTP)/histamine releasing factor (HRF)/histamine pathway and angiogenesis in chronic lymphocytic leukemia (CLL). A total of 153 CLL patients were included. Serum histamine levels were higher in CLL patients. A positive correlation was found between microvessel density (MVD)-mast cell (MC) count; MVD-TCTP/HRF and MC count-TCTP/HRF. Microvessel density, MC and ZAP 70 were significantly higher in TCTP/HRF-positive group. Time to first treatment was shorter in patients with increased MVD and TCTP/HRF. Further data is essential to ascertain the role of TCTP/HRF pathway in tumor angiogenesis and CLL prognosis. (C) 2013 Elsevier Ltd. All rights reserved.