TCTP/HRF pathway and angiogenesis: A feasible intercourse in chronic lymphocytic leukemia

Yagci M., YEGİN Z. A. , AKYÜREK N. , KAYHAN H. , ÖZKURT Z. N. , Sucak G. T. , ...More

LEUKEMIA RESEARCH, vol.37, no.6, pp.665-670, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1016/j.leukres.2013.01.005
  • Title of Journal : LEUKEMIA RESEARCH
  • Page Numbers: pp.665-670


This prospective study was planned to determine the intercourse between translationally controlled tumor protein (TCTP)/histamine releasing factor (HRF)/histamine pathway and angiogenesis in chronic lymphocytic leukemia (CLL). A total of 153 CLL patients were included. Serum histamine levels were higher in CLL patients. A positive correlation was found between microvessel density (MVD)-mast cell (MC) count; MVD-TCTP/HRF and MC count-TCTP/HRF. Microvessel density, MC and ZAP 70 were significantly higher in TCTP/HRF-positive group. Time to first treatment was shorter in patients with increased MVD and TCTP/HRF. Further data is essential to ascertain the role of TCTP/HRF pathway in tumor angiogenesis and CLL prognosis. (C) 2013 Elsevier Ltd. All rights reserved.