Unveiling sarcopenia in Sjögren's syndrome: A hidden comorbidity
JOURNAL OF INVESTIGATIVE MEDICINE, cilt.74, sa.1, ss.34-42, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 74 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1177/10815589251349099
- Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Social Science Premium Collection (ProQuest), Criminology Collection (ProQuest), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.34-42
- Gazi Üniversitesi Adresli: Evet
Özet
Sarcopenia, a progressive loss of skeletal muscle mass and strength, is an emerging yet under-recognized complication in autoimmune diseases. Although extensively studied in conditions such as rheumatoid arthritis and systemic lupus erythematosus, its prevalence and impact in Sj & ouml;gren's syndrome (SS) remain largely unexplored. This study aimed to assess muscle mass and strength in patients with SS, investigate the prevalence of probable sarcopenia and sarcopenia, and identify associated risk factors. A cross-sectional study included 79 SS patients and 72 healthy controls. Handgrip strength (HGS) and bioelectrical impedance analysis were used to assess muscle function. Probable sarcopenia and sarcopenia were defined according to the 2018 EWGSOP2 criteria and specific cutoffs for the Turkish population. Probable sarcopenia was significantly more prevalent in SS patients (63.6%) compared to controls (40.5%, p = 0.005), while sarcopenia was detected in 53.7% of SS patients vs 29.4% of controls (p = 0.01). Older age, lower HGS, reduced skeletal muscle mass index, and delayed diagnosis were significantly associated with probable sarcopenia. Sarcopenia is a prevalent yet overlooked complication in Sj & ouml;gren's syndrome, emphasizing the need for routine muscle function assessments in clinical practice. Targeted interventions and a multidisciplinary approach are crucial to mitigating its impact and improving long-term patient outcomes. Giri & scedil;: Sarkopeni, iskelet kas & imath; k & uuml;tlesi ve g & uuml;c & uuml;nde ilerleyici kay & imath;p ile karakterize edilen bir durum olup, otoimm & uuml;n hastal & imath;klarda giderek daha fazla & ouml;nem kazanan ancak h & acirc;l & acirc; yeterince fark edilmeyen bir komplikasyondur. Romatoid artrit ve sistemik lupus eritematozus gibi hastal & imath;klarda kapsaml & imath;& scedil;ekilde incelenmi & scedil; olmas & imath;na ra & gbreve;men, Sj & ouml;gren sendromu (SS) & ouml;zelindeki prevalans & imath; ve etkisi b & uuml;y & uuml;k & ouml;l & ccedil;& uuml;de ara & scedil;t & imath;r & imath;lmam & imath;& scedil;t & imath;r.Ama & ccedil;: Bu & ccedil;al & imath;& scedil;man & imath;n amac & imath;, SS'li hastalarda kas k & uuml;tlesi ve g & uuml;c & uuml;n & uuml; de & gbreve;erlendirmek, olas & imath; sarkopeni ve sarkopeni prevalans & imath;n & imath; belirlemek ve ili & scedil;kili risk fakt & ouml;rlerini saptamakt & imath;r.Y & ouml;ntemler: Kesitsel tasar & imath;ma sahip bu & ccedil;al & imath;& scedil;maya 79 SS hastas & imath; ve 72 sa & gbreve;l & imath;kl & imath; kontrol dahil edilmi & scedil;tir. Kas fonksiyonu el kavrama g & uuml;c & uuml; (HGS) ve biyoelektrik impedans analizi (BIA) ile de & gbreve;erlendirilmi & scedil;tir. Olas & imath; sarkopeni ve sarkopeni tan & imath;mlar & imath;, 2018 EWGSOP2 kriterlerine ve T & uuml;rk toplumuna & ouml;zg & uuml; e & scedil;ik de & gbreve;erlere g & ouml;re yap & imath;lm & imath;& scedil;t & imath;r.Bulgular: Olas & imath; sarkopeni SS hastalar & imath;nda (%63,6), kontrol grubuna k & imath;yasla (%40,5) anlaml & imath; derecede daha s & imath;k g & ouml;r & uuml;lm & uuml;& scedil;t & uuml;r (p = 0,005). Sarkopeni ise SS grubunda %53,7 oran & imath;nda saptanm & imath;& scedil;ken, kontrol grubunda bu oran %29,4't & uuml;r (p = 0,01). Daha ileri ya & scedil;, d & uuml;& scedil;& uuml;k el kavrama g & uuml;c & uuml;, azalm & imath;& scedil; iskelet kas k & uuml;tle indeksi (SMMI) ve tan & imath;da gecikme, olas & imath; sarkopeni ile anlaml & imath;& scedil;ekilde ili & scedil;kili bulunmu & scedil;tur.Sonu & ccedil;: Sarkopeni, Sj & ouml;gren sendromunda yayg & imath;n ancak & ccedil;o & gbreve;unlukla g & ouml;z ard & imath; edilen bir komplikasyondur. Klinik uygulamalarda kas fonksiyonu de & gbreve;erlendirmelerinin rutine girmesi gereklidir. Hedefe y & ouml;nelik m & uuml;dahaleler ve multidisipliner bir yakla & scedil;& imath;m, sarkopeninin etkisini azaltmak ve uzun vadeli hasta sonu & ccedil;lar & imath;n & imath; iyile & scedil;tirmek a & ccedil;& imath;s & imath;ndan b & uuml;y & uuml;k & ouml;nem ta & scedil;& imath;maktad & imath;r.