Serum bFGF concentrations in gastric cancer patients

Bilgic I., Ozalp N., Tez M., Koc M.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.109, sa.1, ss.8-9, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109 Sayı: 1
  • Basım Tarihi: 2008
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8-9
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Angiogenetic factors play an important role in the formation of new blood vessels involved in the growth and metastatic spread of solid tumors, but there is limited information regarding the clinical significance of serum bFGF levels in gastric cancer patients. Patients and methods: Serum bFGF concentrations were measured by quantitative sandwich enzyme immunoassay technique in 30 controls and in 30 gastric cancer patients before surgery. The association between preoperative serum bFGF levels and clinical pathological features were evaluated. Results: Preoperative serum bFGF levels in patients with gastric cancer were significantly higher than those in control patients (p=0.027). On the other hand; there is no relationship between serum bFGF levels and clinical-pathologic parameters in gastric cancer patients. Conclusion: Circulating bFGF might not be a marker suitable for assessing tumor progression.