Micellar Properties and Antimicrobial Activityof a Mixed Surfactant System Constituted by Sodium Dodecyl Sulfate and Cetylpyridinium Chloride

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Tas D. S., ÇETE S.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, cilt.51, sa.4, ss.580-587, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5530/ijper.51.4.87
  • Dergi Adı: INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.580-587
  • Anahtar Kelimeler: Mixed Micellization, NADS, CPC, Antimicrobial Activity, CLOUD POINT SYSTEM, ANIONIC SURFACTANTS, TETRABUTYLAMMONIUM BROMIDE, AQUEOUS-SOLUTIONS, QUATERNARY-SALTS, MIXTURES, PHASE, HEXAMETHYLENETETRAMINE, BIODEGRADATION, GLYCOPROTEIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Micellar properties of sodium dodecyl sulfate (NaDS) was examined in the presence of cetylpyridinium chloride (CPC) by means of surface tension, viscosity, dye solubilization, cloud point (CP) measurements. Antimicrobial activities of single and binary systems were also investigated. Results: A decrease in critical micelle concentration (CMC) and increase in solubilizing power for NaDS was observed with increasing CPC concentration. At the highest CPC concentration studied (0.1 M), the surface tension decreased up to 51 mN / m. Also, viscosity results showed growth in NaDS micelles (50 mM) up to the 0.1 M CPC concentration. Antimicrobial activity of NaDS, CPC and NaDS in presence of CPC was investigated against ten different strains of bacteria and ayeast which was not investigated up to now. The susceptibilities of the microorganism were determined by the agar diffusion method. The results showed that NaDS and CPC have a antimicrobial activity but NaDS in presence of CPC has not antimicrobial activity on the bacterial and yeast.