Impaired Oxygen Consumption and Muscle Oxygen Utilization with Reduced Physical Activity in Patients with Interstitial Lung Disease Compared with Healthy Controls: A Cross-Sectional Study
European Respiratory Society Congress 2026, Barcelona, İspanya, 5 - 09 Eylül 2026, (Yayınlanmadı)
- Yayın Türü: Bildiri / Yayınlanmadı
- Basıldığı Şehir: Barcelona
- Basıldığı Ülke: İspanya
- Gazi Üniversitesi Adresli: Evet
Özet
Background and Aim: Exercise intolerance and reduced physical activity (PA) are strongly associated with morbidity and mortality in interstitial lung disease (ILD), yet evidence on oxygen consumption and muscle oxygenation is scarce. This study compares pulmonary function, oxygen consumption, muscle oxygenation, and PA levels in patients with ILD to healthy controls.
Methods: Patients with ILD (n=34; DLCO=59.44±18.27%) and healthy controls (n=27) were compared. Pulmonary function (spirometry), exercise capacity (CPET), quadriceps femoris muscle oxygenation (NIRS), and PA levels (activity monitor) were evaluated.
Results: Pulmonary function was significantly reduced in patients with ILD (p<0.05), whereas the FEV1/FVC ratio was significantly higher (p<0.05). During CPET, VO2/kg, VO2%, VCO2, VT, HR, VO2/HR, and SpO2 at peak workload were significantly lower in patients (p<0.05), while ventilatory equivalents (EqO2 and EqCO2) were higher (p<0.001). SmO2-resting, SmO2-minimum, and SmO2-recovery were
higher, however ΔSmO2 was lower in patients (p<0.05). Total and active energy expenditure, PA duration, daily step count, and METs/day were significantly lower in patients; lying-down duration was longer (p<0.05).
Conclusions: Patients with ILD showed impaired pulmonary function, reduced exercise capacity with diminished cardiopulmonary responses, and impaired ventilatory efficiency, along with lower PA levels. Elevated SmO2 and attenuated ΔSmO2 responses suggestaltered peripheral muscle oxygen utilization during exercise rather than solely reduced oxygen availability. Overall, the findings indicate impairments in cardiopulmonary, ventilatory, and peripheral muscle responses in ILD and may inform individualized pulmonary rehabilitation with structured exercise training and PA counselling.