Protection from cyclophosphamide-induced ovarian damage with bone marrow-derived mesenchymal stem cells during puberty

Kilic S., Pinarli F., Ozogul C., Tasdemir N., Sarac G. N., Delibasi T.

GYNECOLOGICAL ENDOCRINOLOGY, cilt.30, sa.2, ss.135-140, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/09513590.2013.860127
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.135-140
  • Anahtar Kelimeler: Apoptosis, chemotherapy, childhood cancer, mesenchymal stem cell, puberty, FUNCTION FOLLOWING CHEMOTHERAPY, HODGKINS-DISEASE, HORMONE AGONIST, CANCER, FERTILITY, PREVENTION, FAILURE, YOUNG, RAT, PRESERVATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: In female cancer survivors, the accelerated loss of primordial follicles may lead to premature ovarian failure. We investigated the protective effects of bone marrow derived mesenchymal stem cells (BMMSC) and gonadotropin releasing hormone analogue (GnRHa) against chemotherapeutic-induced ovarian toxicity in a rat model.