Protection from cyclophosphamide-induced ovarian damage with bone marrow-derived mesenchymal stem cells during puberty


Kilic S., Pinarli F., Ozogul C., Tasdemir N., Sarac G. N. , Delibasi T.

GYNECOLOGICAL ENDOCRINOLOGY, vol.30, no.2, pp.135-140, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.3109/09513590.2013.860127
  • Journal Name: GYNECOLOGICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.135-140
  • Keywords: Apoptosis, chemotherapy, childhood cancer, mesenchymal stem cell, puberty, FUNCTION FOLLOWING CHEMOTHERAPY, HODGKINS-DISEASE, HORMONE AGONIST, CANCER, FERTILITY, PREVENTION, FAILURE, YOUNG, RAT, PRESERVATION

Abstract

Objective: In female cancer survivors, the accelerated loss of primordial follicles may lead to premature ovarian failure. We investigated the protective effects of bone marrow derived mesenchymal stem cells (BMMSC) and gonadotropin releasing hormone analogue (GnRHa) against chemotherapeutic-induced ovarian toxicity in a rat model.