Extrastriatal binding of [I-123]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

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Koch W., Unterrainer M., Xiong G., Bartenstein P., Diemling M., Varrone A., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.41, sa.10, ss.1938-1946, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 10
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s00259-014-2785-8
  • Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1938-1946
  • Anahtar Kelimeler: Dopamine transporter, Serotonin transporter, [I-123]FP-CIT, Extrastriatal binding, SPECT, Gender difference, Age effects, SEROTONIN TRANSPORTER AVAILABILITY, H-3 PAROXETINE BINDING, STRIATAL DOPAMINE TRANSPORTERS, HUMAN-BRAIN, PARKINSONS-DISEASE, I-123-FP-CIT SPECT, UPTAKE SITES, I-123-BETA-CIT SPECT, COMPUTED-TOMOGRAPHY, IMIPRAMINE BINDING
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose Apart from binding to the dopamine transporter (DAT), [I-123]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.