Extrastriatal binding of [I-123]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.41, sa.10, ss.1938-1946, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 10
- Basım Tarihi: 2014
- Doi Numarası: 10.1007/s00259-014-2785-8
- Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1938-1946
- Anahtar Kelimeler: Dopamine transporter, Serotonin transporter, [I-123]FP-CIT, Extrastriatal binding, SPECT, Gender difference, Age effects, SEROTONIN TRANSPORTER AVAILABILITY, H-3 PAROXETINE BINDING, STRIATAL DOPAMINE TRANSPORTERS, HUMAN-BRAIN, PARKINSONS-DISEASE, I-123-FP-CIT SPECT, UPTAKE SITES, I-123-BETA-CIT SPECT, COMPUTED-TOMOGRAPHY, IMIPRAMINE BINDING
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Purpose Apart from binding to the dopamine transporter (DAT), [I-123]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.