THE EFFECT OF THE MALE CONTRACEPTIVE AGENT GOSSYPOL ACETIC-ACID ON MOUSE BONE-MARROW CELLS INVIVO - MICRONUCLEI AND MITOTIC INDEX


ORHAN G., EKMEKCI A., MENEVSE S.

CONTRACEPTION, cilt.47, ss.377-385, 1993 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 47 Konu: 4
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0010-7824(93)90035-6
  • Dergi Adı: CONTRACEPTION
  • Sayfa Sayıları: ss.377-385

Özet

In this work the genotoxic effect of gossypol acetic acid (gossypol) was evaluated by determining the frequency of micronuclei and mitotic index in male mouse bone marrow cells in vivo. Bone marrow cells were collected at 24th hour after the single intraperitoneal (20, 40, and 80 mug/g) administration of gossypol. Polychromatic erythrocytes (PCEs) in the bone marrow were then evaluated with respect to micronuclei frequency. The dose-dependent increase in the micronuclei frequency was observed. However, when compared with the control group, the increase was not found to be significiant (P>0.05). Also the mitotic index values were not found to be different from those control values (P>0.05). The results suggest that gossypol is not a clastogenic and mutagenic agent in mouse bone marrow cells in vivo.