Endocrowns were manufactured using different restorative materials to evaluate the marginal adaptation and fracture strength. Fifty endodontically treated mandibular first molar teeth were divided into five groups (n= 10). Endocrowns were obtained from lithium disilicate glass ceramic ingots by heat-press technique (Group e.max Press: GEP), and from feldspathic blocks (Group Cerec: GC), polymer infiltrated ceramic network blocks (Group Enamic: GE), lithium disilicate glass ceramic blocks (Group e.max CAD: GEC), and zirconia-reinforced glass ceramic blocks (Group Suprinity: GS) by CAD/CAM technique. After thermocycling, marginal adaptation was evaluated under scanning electron microscope at x200 magnification. The specimens' fracture strengths were tested in universal test machine, and fracture types were evaluated. Statistical analyses were performed with Kruskal-Wallis test. The highest marginal gap value was found in GEP, but no significant differences were determined among the other four groups (p > .05). Significant differences were observed among the groups in terms of fracture strength (p= .019). The fracture strength values of GEC were significantly higher than GE, GC, and GS (p < .05). Values were not significantly different between the GEC and GEP groups (p > .05). CAD/CAM endocrowns showed better marginal adaptation than heat-pressed endocrowns. Clinically acceptable marginal gaps were seen in both endocrown types. Both CAD/CAM and heat-pressed lithium disilicate glass ceramic endocrowns showed higher fracture strength.