The periodic table of urea derivative: small molecules of zinc(II) and nickel(II) of diverse antimicrobial and antiproliferative applications


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Banti C. N. , POYRAZ M., Sainis I., SARI M. , Rossos G., Kourkoumelis N., ...More

MOLECULAR DIVERSITY, vol.24, no.1, pp.31-43, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1007/s11030-018-09909-0
  • Title of Journal : MOLECULAR DIVERSITY
  • Page Numbers: pp.31-43

Abstract

Two complexes of Zn(II) and Ni(II) ions with the urea derivative, 2-benzimidazolyl-urea (BZIMU), of formulae [ZnBZIMU)(2)(H2O)](NO3)(2) (1) and [Ni(BZIMU)(2)(CH3CH2OH)(2)](NO3)(2) (2) were synthesized and characterized by their melting point, elemental analysis, spectroscopic techniques (FTIR, UV-Vis and H-1-NMR), High-resolution mass spectroscopy (HRMS), molar conductivity and thermogravimetric analysis. The crystal structures of 1-2 were determined by X-ray diffraction analysis. The antiproliferative activity of 1-2 was tested in vitro against human adenocarcinoma cell lines: cervix (HeLa) and breast (MCF-7). Their toxicity was surveyed against normal human fetal lung fibroblast cells (MRC-5). The bioactivity mechanism of 1-2 and their related analogues of copper and silver metallodrugs are rationalized by the means of computations. The antimicrobial activity of 1-2 against Escherichia coli (E. coli) is also evaluated.Graphical AbstractThe complexes [ZnBZIMU)(2)(H2O)](NO3)(2) (1) and [Ni(BZIMU)(2)(CH3CH2OH)(2)](NO3)(2) (2) (BZIMU= 2-Benzimidazolyl-urea), were tested in vitro against HeLa and MCF-7 cells. Their toxicity was surveyed against normal MRC-5 cells. The association of the microbiota with the antiproliferative activity of 1-2 was investigated against Escherichia coli.