Determination of Paracetamol Based on 3-amino-4H-1,2,4-triazole Coated Glassy Carbon Surface in Pharmaceutical Sample

Uzun D.

ELECTROANALYSIS, cilt.33, sa.7, ss.1699-1706, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/elan.202100002
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1699-1706
  • Anahtar Kelimeler: Modified electrode, 3-amino-4H-1, 2, 4-triazole, paracetamol, pharmaceutical
  • Gazi Üniversitesi Adresli: Evet

Özet

In this present study, to determine paracetamol, an electroanalytical method is presented using differential pulse voltammetry (DPV) at 3-amino-4H-1,2,4-triazole (3AT) coated glassy carbon (GC) electrode. The electrochemical characterization and electron transfer behavior of this prepared electrode in the mixture of K-4[Fe(CN)(6)]/K-3[Fe(CN)(6)] contains 0.1 M KCl was confirmed by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods. Furthermore, scanning electron microscopy (SEM) was used to observe morphological structures of the bare and modified surfaces. The effect of pH was studied on the redox reaction of paracetamol in phosphate buffer in the range of pH 3.0-9.0. The limit of detection was 0.043 mu M (3 s/m) for 3AT-GC electrode. The developed electrode was successfully utilized in pharmaceutical samples.