Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.49, sa.1, ss.198-210, 2025 (Scopus)
Objective: Cancer is a type of chronic and non-contagious disease that is common in our country and in the world. Chemotherapy, immunotherapy, radiotherapy, phytotherapy, palliative treatments and surgical methods are used in cancer treatment. This review aims to evaluate the results of in vitro, in vivo and clinical studies examining the effects of flavonoids on the prevention and treatment of lung cancer. In addition, the mechanisms by which flavonoids are used to prevent and treat lung cancer were investigated. Result and Discussion: There are many studies on the efficacy of flavonoids in lung, breast, ovarian, esophageal and colorectal cancers. In vitro, in vivo and clinical study findings are also available to evaluate their efficacy especially in lung cancer. In the light of these findings, flavonoids show anticancer activity with many effects including antioxidant, anti-inflammatory, antiproliferative activities, inhibition of bioactivating enzymes and induction of detoxifying enzymes. In addition, flavonoids selectively induce apoptosis of lung cancer cells, thereby providing anticancer effects and do not harm normal healthy cells. In conclusion, flavonoids inhibit lung carcinogenesis in preclinical studies and have the capacity to target the signaling pathways involved in lung carcinogenesis, but much more clinical studies are needed.