Vaginal Fistula in a Patient with Relapsed Ovarian Cancer and Amelanotic Melanoma

Muallem M. Z., Yildiz S., Arsenic R., Trefzer U., Sehouli J.

ANTICANCER RESEARCH, vol.32, no.5, pp.1737-1742, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 5
  • Publication Date: 2012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1737-1742
  • Gazi University Affiliated: No


Background: Malignant vaginal melanoma is extremely rare and accounts for fewer than 0.3% of all melanomas in women. Amelanotic malignant melanoma is a subtype of melanoma with little or no pigment on visual inspection. The simultaneous occurrence of amelanotic melanoma of the vagina and serous ovarian cancer is extremely rare. Case Report: A 61-year-old patient was referred to our hospital with recurrent ovarian cancer in association with a vaginorectal fistula. The,first diagnosis was performed in 2009. The patient underwent multi-ovarian cancer recurrences after the primary cytoreductive surgery, especially in the vaginal vault, with several different lines of chemotherapy. The pathological results on this occasion demonstrated recurrent ovarian cancer with a component of amelanotic melanoma in the region of a vaginorectal fistula. Conclusion: We recommend detailed immunohistochemical staining, especially for recurrent ovarian cancer in combination with abnormal localizations or manifestations, in order to reveal any associations with another tumor.