DNA Methylation Map of Human Atherosclerosis

Zaina S., Heyn H., Javier Carmona F., Varol N., Sayols S., Condom E., ...Daha Fazla

CIRCULATION-CARDIOVASCULAR GENETICS, cilt.7, sa.5, ss.692-700, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1161/circgenetics.113.000441
  • Dergi Adı: CIRCULATION-CARDIOVASCULAR GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.692-700
  • Anahtar Kelimeler: aorta, DNA methylation, epigenomics, genome-wide association analysis, EPIGENETIC REGULATION, CELL PROLIFERATION, ANGIOTENSIN-II, RECEPTOR, EXPRESSION, DISEASE, GENES, MICROARRAY, MIGRATION, SITES
  • Gazi Üniversitesi Adresli: Evet

Özet

Background Epigenetic alterations may contribute to the development of atherosclerosis. In particular, DNA methylation, a reversible and highly regulated DNA modification, could influence disease onset and progression because it functions as an effector for environmental influences, including diet and lifestyle, both of which are risk factors for cardiovascular diseases.