ALTERATION BY ILOPROST OF THE VASOSPASTIC EFFECTS OF ENDOTHELIN-1 IN RABBIT CEREBRAL VESSELS


KESKIL I., BAYKANER M., SENCER H., ATAOGLU O., ILGIT E. T. , ERDOGAN B., ...More

NEUROREPORT, vol.5, no.9, pp.1089-1092, 1994 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 9
  • Publication Date: 1994
  • Doi Number: 10.1097/00001756-199405000-00017
  • Journal Name: NEUROREPORT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1089-1092
  • Gazi University Affiliated: Yes

Abstract

THE reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluated by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of the parameters measured.