Infliximab administration reduces neuronal apoptosis on the optic pathways in a rabbit hydrocephalus Model: A preliminary report

KURT G., Cemil B., BÖRCEK A. Ö., Borcek P., AKYÜREK N., SEPİCİ DİNÇEL A., ...Daha Fazla

BRITISH JOURNAL OF NEUROSURGERY, cilt.24, sa.3, ss.275-279, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/02688691003653751
  • Dergi Adı: BRITISH JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.275-279
  • Anahtar Kelimeler: Hydrocephalus, apoptosis, tumor necrosis factor alpha, infliximab, TUMOR-NECROSIS-FACTOR, NORMAL-PRESSURE HYDROCEPHALUS, SPINAL-CORD-INJURY, WEGENERS-GRANULOMATOSIS, CEREBROSPINAL-FLUID, TNF-ALPHA, BRAIN, DAMAGE, RAT, SULFATIDE
  • Gazi Üniversitesi Adresli: Evet

Özet

Object. This study was designed to explore the effects of infliximab on the optic pathway in kaolin induced hydrocephalus rabbit model. Methods. After injection of kaolin to the cisterna magna of 12 New Zealand rabbits for induction of hydrocephalus, animals were divided into 2 groups and received either infliximab or normal saline. The intracranial pressure measurement was performed 2 times; firstly, before kaolin injection and secondly, before decapitation to ensure that the rabbits had hydrocephalus. After 2 weeks, animals were decapitated. Results. Apoptotic cells in the lateral geniculate body, optic radiation, and optic disc were counted with TUNEL method. Apoptotic cell counts of the lateral geniculate body and the optic radiation were showed statistically significant difference between the infliximab group and the control group. Conclusions. This study suggests that infliximab may have a neuroprotective effect through its anti-apoptotic property on hydrocephalus induced optic pathways injury.