Akademik Veri Yönetim Sistemi
Studies in Natural Products Chemistry, Elsevier B.V., ss.41-53, 2026
The management of diabetes mellitus is a major global challenge that requires innovative approaches to enhance the quality of life and outcomes for those impacted. Recently, there has been increasing interest in using prebiotics to manage diabetes. Prebiotics are non-digestible food components that selectively stimulate the growth and/or activity of beneficial bacteria in the gut. They have emerged as promising agents due to their ability to modulate gut microbiota composition and function. Prebiotics are thought to help the treatment of diabetes by modulating the intestinal microbiota, improving intestinal barrier function, and regulating metabolic pathways. However, evidence from preclinical studies, clinical trials, and observational studies on the effects of prebiotic supplementation on glucose regulation, insulin sensitivity, and other metabolic parameters in diabetic patients is available in the literature. This chapter provides a comprehensive overview of the current relationship between prebiotics and the management of diabetes mellitus. Challenges and future directions in prebiotic research related to diabetes mellitus management are also discussed. It underscores the imperative for additional investigation into optimal dosing regimens, the identification of prebiotic substrates with maximal efficacy, and the exploration of tailored interventions predicated upon individual gut microbiota composition. In sum, this review elucidates the potential of prebiotics as an innovative adjunctive therapeutic modality in managing diabetes mellitus, emphasizing the imperative for sustained research efforts within this dynamic and swiftly advancing domain.