Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats


Karen M., YÜKSEL O. , AKYÜREK N. , Ofluoglu E., ÇAĞLAR K. , Sahin T. T. , ...More

JOURNAL OF SURGICAL RESEARCH, vol.160, no.1, pp.139-144, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 160 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jss.2009.02.008
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.139-144

Abstract

Background. Acute necrotizing pancreatitis is a severe acute inflammatory disease of the pancreas that can lead to extrapancreatic organ involvement. Supervening lung injury is an important clinical entity determining the prognosis of the patient. Probiotics are dietary supplements known to reduce or alter inflammation and inflammatory cytokines. In the present study, we hypothesize that probiotics may reduce lung injury by reducing bacterial translocation, which results in reduced infection, inflammation, and generation of proinflammatory cytokines in an experimental model of acute necrotizing pancreatitis.