Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

Karen M., YÜKSEL O., AKYÜREK N., Ofluoglu E., ÇAĞLAR K., Sahin T. T., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.160, sa.1, ss.139-144, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 160 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jss.2009.02.008
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.139-144
  • Anahtar Kelimeler: acute necrotizing pancreatitis, lung injury, probiotic, bacterial translocation, BACTERIAL OVERGROWTH, PHOSPHOLIPASE-A2, COMPLICATIONS, TRANSLOCATION, PROPHYLAXIS, SURFACTANT, MORTALITY, TRIAL
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Acute necrotizing pancreatitis is a severe acute inflammatory disease of the pancreas that can lead to extrapancreatic organ involvement. Supervening lung injury is an important clinical entity determining the prognosis of the patient. Probiotics are dietary supplements known to reduce or alter inflammation and inflammatory cytokines. In the present study, we hypothesize that probiotics may reduce lung injury by reducing bacterial translocation, which results in reduced infection, inflammation, and generation of proinflammatory cytokines in an experimental model of acute necrotizing pancreatitis.