Evaluation of Advanced Oxidation Protein Products (AOPP) and Superoxide Dismutase (SOD) Tissue Levels in Patients with Nasal Polyps

Zorlu M. E., UYGUR K. K., Yilmaz N. S., Demirel O. O., AYDİL U., KIZIL Y., ...Daha Fazla

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, cilt.74, ss.4824-4830, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s12070-022-03124-y
  • Dergi Adı: INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.4824-4830
  • Anahtar Kelimeler: Advanced oxidation protein products, Nasal polyposis, Oxidative stress, Superoxide, Dismutase, FREE-RADICALS, STRESS, ANTIOXIDANTS, MARKER, ACTIVATION, DAMAGE
  • Gazi Üniversitesi Adresli: Evet

Özet

The aim of this study is to eveluate levels of advanced oxidation protein products (AOPP) which are thought to increase in the polyp tissue and superoxide dismutase (SOD), an antioxidant enzyme, with using specthrophotometry in polyp tissue and healthy mucosa. 30 nasal polyp patients without inflammatory disease except for nasal polyposis were included in the study. The control group consisted of 18 patients who did not have allergy, asthma, inflammatory and granulomatous disease and planned surgery due to septum deviation and concha hypertrophy. AOPP and SOD tissue levels were measured by spectrophotometry in polyp tissue specimens taken from patients with nasal polyps and concha samples taken from patients in the control group. The mean AOPP tissue level of patients in the nasal polyposis group was statistically significantly higher than the control group. (p < 0.05). The mean SOD activity level was significantly lower in the nasal polyposis group than the control group. (p < 0.05) As a result of this study, high AOPP levels in polyp tissue and low SOD levels in polyp tissue compared to healthy nasal mucosa, oxidative stress plays an important role in nasal polyp development.