Akademik Veri Yönetim Sistemi
Biomedical Materials and Devices, cilt.3, sa.1, ss.299-316, 2025 (Scopus)
Molecular imprinting is a technique that enables the generation of customized binding sites for specific molecules. Molecularly imprinted polymers are versatile materials distinguished by their ease of synthesis, exceptional stability even under harsh conditions, prolonged lifespan, and the establishment of predetermined selective cavities through the polymerization process. The molecular imprinting technique, often preferred in purification and separation studies due to its superior properties, has also been utilized in medical applications in recent years. It frequently emerges, particularly in the diagnosis of cancer and microbial diseases. High accuracy percentage and the number of reuses, along with low cost, are among the preferred reasons for its use in diagnoses. Additionally, the rapid response of molecularly imprinted biomaterials shortens the duration of diagnoses. Furthermore, tissue engineering has also focused on exploring the potential of creating bioactive scaffolds with superior recognition properties as molecularly imprinted biomaterials in recent years. In the pharmaceutical sector, molecularly imprinted biomaterials are also utilized for their superior recognition and separation properties. There is considerable research on the use of molecularly imprinted polymers in the separation of chiral enantiomers, for example. Compared to traditional methods, their lower cost and specificity contribute to the increased utilization of these biomaterials. This review aims to showcase the rapidly increasing utilization and advancements of biomaterials prepared using molecular imprinting techniques in recent years in the pharmaceutical field, particularly in the diagnosis of cancer and microbial diseases, as well as in regenerative medicine.