Radiolabelled somatostatin analogues are of potential value in the imaging of somatostatin receptor-positive tumours. Recently, somatostatin receptors have been demonstrated in the osteoblast precursor cells. In this preliminary study, we evaluated the uptake characteristics of indium-111 octreotide in two benign and two malignant bone tumours, Tracer accumulation was observed in all four cases, and overall lesion to background ratio (mean +/- SD) was 2.74 +/- 0.84 and 2.98 +/- 1.49 at 4 h and 24 h, respectively. There was no clear relationship between In-111-octreotide accumulation and the benign or malignant nature of the tumour. In one patient, tracer uptake was inhibited by unlabelled octreotide administration. These results suggest that In-111-octreotide can be taken up by benign and malignant bone tumours. The inhibition of tumour uptake by treatment with cold octreotide supports the concept that specific uptake mechanisms are responsible for In-111-octreotide deposition by bone rumours.