Indium-111 octreotide scintigraphy in patients with bone tumours of the extremities


Inanir S., Unlu M., Okudan B., Cila E., Atik S.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol.23, no.8, pp.987-990, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 8
  • Publication Date: 1996
  • Doi Number: 10.1007/bf01084376
  • Title of Journal : EUROPEAN JOURNAL OF NUCLEAR MEDICINE
  • Page Numbers: pp.987-990

Abstract

Radiolabelled somatostatin analogues are of potential value in the imaging of somatostatin receptor-positive tumours. Recently, somatostatin receptors have been demonstrated in the osteoblast precursor cells. In this preliminary study, we evaluated the uptake characteristics of indium-111 octreotide in two benign and two malignant bone tumours, Tracer accumulation was observed in all four cases, and overall lesion to background ratio (mean +/- SD) was 2.74 +/- 0.84 and 2.98 +/- 1.49 at 4 h and 24 h, respectively. There was no clear relationship between In-111-octreotide accumulation and the benign or malignant nature of the tumour. In one patient, tracer uptake was inhibited by unlabelled octreotide administration. These results suggest that In-111-octreotide can be taken up by benign and malignant bone tumours. The inhibition of tumour uptake by treatment with cold octreotide supports the concept that specific uptake mechanisms are responsible for In-111-octreotide deposition by bone rumours.