Hepatic and renal tissue selenium levels in a mouse model of candidiasis

Kalkanci A. , Bukan N. , Sancak B., Kustimur S.

TRACE ELEMENTS AND ELECTROLYTES, cilt.22, sa.4, ss.272-276, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.5414/tep22272
  • Sayfa Sayıları: ss.272-276


Objective: Candidemia is a form of sepsis resulting in a complicated inflammatory response in living organisms. There is no sufficient data about selenium levels in candidiasis. Methods: Selenium levels were analyzed by atomic absorption spectrophotometry in different organs of mouse model of candidiasis. Results: We found that selenium levels increased in hepatic tissue of the mice (1045.9 +/- 166.29 ng/ml), while they decreased in renal tissue (518.48 +/- 258.18 ng/ml) when compared with control groups (p > 0.001). Conclusions: This can be explained by the different selenium uptake of the metabolic pathways in renal and hepatic tissues.