Synthesis, characterization, and biological evaluation of Cu(II) complexes with the proton transfer salt of 2,6-pyridinedicarboxylic acid and 2-amino-4-methylpyridine

YENİKAYA C., BÜYÜKKIDAN N., SARI M., Kesli R., İLKİMEN H., BÜLBÜL M., ...Daha Fazla

JOURNAL OF COORDINATION CHEMISTRY, cilt.64, sa.19, ss.3353-3365, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 19
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1080/00958972.2011.620608
  • Dergi Adı: JOURNAL OF COORDINATION CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3353-3365
  • Anahtar Kelimeler: Proton transfer, Cu(II) complex, Crystal structure, Staphylococcus aureus, Escherichia coli, Bacterial growth, MOLECULAR-STRUCTURE, DIPICOLINIC ACID, METAL-COMPLEXES, SPECTROSCOPIC PROPERTIES, MANGANESE(II) COMPLEXES, COORDINATION CHEMISTRY, MAGNETIC-PROPERTIES, CRYSTAL-STRUCTURES, BACTERIAL-SPORES, COPPER(II)
  • Gazi Üniversitesi Adresli: Evet

Özet

A proton transfer compound, (Hamp)(+)(Hdipic)(-)center dot 1.5H(2)O (1), and Cu(II) complexes, [Cu(dipic)(amp)(H2O)]center dot[Cu(dipic)(amp)]center dot H2O center dot CH3COOH (2) and [Cu(dipic)(amp)Cu(dipic) (amp)(H2O)Cu(dipic)(amp)(H2O)]center dot 3H(2)O (3), have been synthesized from 2,6-pyridinedicarboxylic acid (H(2)dipic) and 2-amino-4-methylpyridine (amp). They have been characterized by elemental, spectral (H-1-NMR, IR, and UV-Vis), and thermal analyses. In addition, magnetic measurements and single crystal X-ray diffraction have been applied to 2 and 3. The crystal structure of 2 consists of two independent and different cationic sites with Cu2+ ions. Cu1 is four-coordinate in a distorted square planar geometry and Cu2 is five-coordinate in a distorted square pyramid. Compound 3 has three independent and different cationic sites of Cu2+ ions. Cu1 is four-coordinate in a distorted square planar geometry and Cu2 and Cu3 have five-coordinate, distorted square-pyramidal sites. Inhibitory effects of 1, 2, and 3 have been studied and compared with starting compounds (amp and H2dipic) on bacterial growth of Staphylococcus aureus and Escherichia coli cultures. Compounds 2 and 3 prevent bacterial growth although 1 has no effect. Compounds 2 and 3 are more effective than amp and H(2)dipic, at similar concentrations on preventing bacterial growth for both organisms.