The protective effect of Ginkgo biloba extract on CCl4-induced hepatic damage

Özenirler S., DİNCER S., AKYOL G., ÖZOĞUL C., ORHAN E.

Acta Physiologica Hungarica, cilt.85, sa.3, ss.277-285, 1997 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 3
  • Basım Tarihi: 1997
  • Dergi Adı: Acta Physiologica Hungarica
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.277-285
  • Anahtar Kelimeler: Cci4, Ginkgo biloba, Lipid peroxidation, Liver, Microscopy
  • Gazi Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the protective effect of Ginkgo biloba extract on CCI4-induced hepatic damage in rats. Hepatic malondialdehyde, glutathione and hydroxyproline levels and histopathologic alterations in liver specimens were assessed. 200 mg/kg/day Ginkgo biloba extract were given orally to the animals for 10 days, then a single dose of 2 ml/kg b.w. carbon tetrachloride was, administered intraperitoneally. Ginkgo biloba extract treatment reduced hepatic malondialdehyde levels significantly (p<0.05), but did not alter glutathione (p<0.05) and hydroxyproline levels (p<0.05). The light and electron microscopic findings showed that Ginkgo biloba extract limited the CCI4-induced hepatocyte necrosis and atrophy. These results suggest that this extract may protect the hepatocytes from carbon tetrachloride-induced liver injury.