INFLUENCE OF THE PREPARATION METHOD ON THE DISSOLUTION CHARACTERISTICS OF IBUPROFEN WITH LOW-MOLECULAR GELATIN

ACARTURK F., TAKKA S., AGABEYOGLU I., OZKAN Y., YALIM G., SIMSEK R.

PHARMAZIE, cilt.48, sa.10, ss.761-763, 1993 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 10
  • Basım Tarihi: 1993
  • Dergi Adı: PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.761-763
  • Gazi Üniversitesi Adresli: Hayır

Özet

The effect of the preparation method on the dissolution characteristics of ibuprofen (1)-low-molecular gelatin (LMG) solid mixtures has been studied. The 1-LMG solid mixtures in a weight ratio of 1:2 were prepared by the kneading, grinding and co-precipitating methods and dissolution of these was carried out. The interaction of 1 with LMG in aqueous solution and in the solid state was examined by solubility analysis, powder X-ray diffractometry and Differential Scanning Calorimetry (DSC) measurements. Also, the surface tension measurements of samples were performed.