Effect of Intraoperative Platelet-Rich Plasma and Fibrin Glue Application on Skin Flap Survival


Findikcioglu F., FINDIKÇIOĞLU K., Yavuzer R., Lortlar N., Atabay K.

JOURNAL OF CRANIOFACIAL SURGERY, vol.23, no.5, pp.1513-1517, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1097/scs.0b013e3182597ce6
  • Journal Name: JOURNAL OF CRANIOFACIAL SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1513-1517
  • Keywords: Platelet-rich plasma, fibrin glue, thrombin, flap survival, ENDOTHELIAL GROWTH-FACTOR, THERAPEUTIC ANGIOGENESIS, RAT, ANASTOMOSES, IMPROVEMENT, EXPRESSION, SEALANT, VEGF, GEL

Abstract

The experiment was designed to compare the effect of intraoperative platelet-rich plasma (PRP) and fibrin glue application on skin flap survival. In this study, bilateral epigastric flaps were elevated in 24 rats. The right-side flaps were used as the control of the left-side flaps. Platelet-rich plasma, fibrin glue, and thrombin had been applied under the flap sites in groups 1, 2, and 3, respectively. Five days later, all flap pedicles were ligated. Necrotic area measurements, microangiography, and histologic and immunohistochemical evaluations were performed to compare the groups.