Effect of Intraoperative Platelet-Rich Plasma and Fibrin Glue Application on Skin Flap Survival

Findikcioglu F., FINDIKÇIOĞLU K. , Yavuzer R., Lortlar N., Atabay K.

JOURNAL OF CRANIOFACIAL SURGERY, cilt.23, sa.5, ss.1513-1517, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Konu: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/scs.0b013e3182597ce6
  • Sayfa Sayıları: ss.1513-1517


The experiment was designed to compare the effect of intraoperative platelet-rich plasma (PRP) and fibrin glue application on skin flap survival. In this study, bilateral epigastric flaps were elevated in 24 rats. The right-side flaps were used as the control of the left-side flaps. Platelet-rich plasma, fibrin glue, and thrombin had been applied under the flap sites in groups 1, 2, and 3, respectively. Five days later, all flap pedicles were ligated. Necrotic area measurements, microangiography, and histologic and immunohistochemical evaluations were performed to compare the groups.