Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow

ERDEM Ş. R. , Emre-Aydingoz S., ATİLLA P., Cakar A. N. , DALKARA T., Bolay H. B. , ...Daha Fazla

LIFE SCIENCES, cilt.88, ss.753-760, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 88
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.lfs.2011.02.015
  • Dergi Adı: LIFE SCIENCES
  • Sayfa Sayıları: ss.753-760


Aims: To bring further insight into the mechanism of cyclosporine A (CsA)-induced hepatotoxicity, the acute effect of CsA on local hepatic blood flow (LHBF) and its association with systemic hemodynamics, histopathological and biochemical indicators of liver toxicity were studied in guinea pigs in vivo. The association of endothelin (ET) and/or Cremophor-EL (C-EL, vehicle in parenteral CsA preparation) with CsA effects was also investigated.