LIFE SCIENCES, vol.88, pp.753-760, 2011 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus
Cyclosporine A, Endothelin, Hepatotoxicity, Guinea pigs, Laser Doppler flowmeter, ISOLATED GALLBLADDER STRIPS, TRANSPLANT RECIPIENTS, EPITHELIAL-CELLS, NITRIC-OXIDE, IN-VITRO, RAT, LIVER, CONTRACTION, CHOLESTASIS, INVOLVEMENT
Aims: To bring further insight into the mechanism of cyclosporine A (CsA)-induced hepatotoxicity, the acute effect of CsA on local hepatic blood flow (LHBF) and its association with systemic hemodynamics, histopathological and biochemical indicators of liver toxicity were studied in guinea pigs in vivo. The association of endothelin (ET) and/or Cremophor-EL (C-EL, vehicle in parenteral CsA preparation) with CsA effects was also investigated.