Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow


ERDEM Ş. R. , Emre-Aydingoz S., ATİLLA P., Cakar A. N. , DALKARA T., Bolay H. B. , ...More

LIFE SCIENCES, vol.88, pp.753-760, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 88
  • Publication Date: 2011
  • Doi Number: 10.1016/j.lfs.2011.02.015
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.753-760
  • Keywords: Cyclosporine A, Endothelin, Hepatotoxicity, Guinea pigs, Laser Doppler flowmeter, ISOLATED GALLBLADDER STRIPS, TRANSPLANT RECIPIENTS, EPITHELIAL-CELLS, NITRIC-OXIDE, IN-VITRO, RAT, LIVER, CONTRACTION, CHOLESTASIS, INVOLVEMENT

Abstract

Aims: To bring further insight into the mechanism of cyclosporine A (CsA)-induced hepatotoxicity, the acute effect of CsA on local hepatic blood flow (LHBF) and its association with systemic hemodynamics, histopathological and biochemical indicators of liver toxicity were studied in guinea pigs in vivo. The association of endothelin (ET) and/or Cremophor-EL (C-EL, vehicle in parenteral CsA preparation) with CsA effects was also investigated.