The cytoprotective effect of Iloprost against carbon tetrachloride induced necrosis in rat liver

Bozkurt S., Ersoy E., Tekyn H., Bayram O., Anadol Z. , Onuk E., ...Daha Fazla

Research Communications in Molecular Pathology and Pharmacology, cilt.95, sa.3, ss.343-346, 1997 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Konu: 3
  • Basım Tarihi: 1997
  • Dergi Adı: Research Communications in Molecular Pathology and Pharmacology
  • Sayfa Sayıları: ss.343-346


The aim of this study was to investigate the cytoprotective effect of Iloprost on the liver against carbon tetrachloride induced necrosis. The serum histamine-like activity was found to be increased when compared with that of controls after treatment with carbon tetrachloride for 18 weeks while prostaglandin E2 - and leukotriene C4 - like activities were unchanged. After pretreatment with Iloprost for 18 weeks the increased activity of histamine was found to be unchanged while prostaglandin E2 - like activity was increased. It is concluded that Iloprost protects the liver against carbon tetrachloride-induced damage and reduces the level of histamine that has a role in the pathogenesis of portal hypertension.