Comparison of hippocampal interleukin-6 immunoreactivity after exhaustive exercise in both exercise-trained and untrained rats


Aral L. A. , Pinar L., Goktas G., Deveden E. Y. , Erdogan D.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.44, no.4, pp.560-568, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.3906/sag-1305-23
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.560-568
  • Keywords: Exhaustive exercise, hippocampus, interleukin-6, SKELETAL-MUSCLE, VOLUNTARY EXERCISE, ADIPOSE-TISSUE, INFLAMMATION, CYTOKINES, HUMANS, BRAIN, MICE, IL-6, MECHANISMS

Abstract

Background/aim: Exhaustive exercise is a strong stress factor and can impact cytokine production in the brain. Interleukin-6 (IL-6) is produced in greater amounts than any other cytokine in response to exercise, and its effects are closely related to both exercise duration and intensity. In this study, we measured the differences between the amount of IL-6 reactivity of the hippocampus after an exhaustive session of running in long-term exercise-trained and untrained rats.