Second branchial arches anomalies are the most common branchial anomalies. Usually sinuses and fistulas are encountered in younger ages, while cysts are observed in adolescent or adults. Early diagnosis and treatment decreases recurrence by preventing infection, which causes adhesions in the tissue plans. Definitive treatment for these lesions are surgical excision. The aim of this study is to report our clinical experience in second brachial duct anomalies with the review of the literature.