Secondline chemotherapy versus best supportive care in patient with malignant pleural mesothelioma: A retrospective study


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Mutlu H., Buyukcelik A., Karaca H., Aksahin A., Berk V., Aslan T., ...Daha Fazla

Asian Pacific Journal of Cancer Prevention, cilt.14, sa.6, ss.3887-3889, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.7314/apjcp.2013.14.6.3887
  • Dergi Adı: Asian Pacific Journal of Cancer Prevention
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3887-3889
  • Anahtar Kelimeler: Best supportive care., Mesothelioma, Secondline chemotherapy, Survival
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Mesothelioma is a rare neoplasm arising from mesothelial surfaces with the malignant pleural mesothelioma (MPM) as the most common form. Secondline chemotherapy in MPM is still controversial and in this study we evaluated whether it is superior to best supportive care. Materials and Methods: A total of 51 patients with MPM from Acibadem Kayseri Hospital, Kayseri Training and Research Hospital and Erciyes University were analyzed retrospectively. The patients treated with secondline chemotherapies (SLCT) were compared with those treated with best supportive care (BSC) for overall survival. Results: The median overall survival (OS) for firstline chemotherapyg →SLCT and firstline chemotherapyg →BSC groups were 20.3 and 14.7 months respectively (p=0.079). After firstline chemotherapy the median OS for SLCT and BSC were 5.9 and 4.7 months (p=0.355). Discussion: Although there was a trend for improvement in overall survival in patients treated with secondline chemotherapy, the difference was not statistically significant. Our results do not support the proposal that secondline chemotherapy could be effective in patients with MPM.